FYI -
here are the leaderboards from a 100-year sim using SkyDog's statistic settings, with no change to the player development modifiers. Twenty-four teams with five levels of minors each.
I'm very happy with these results. Career HR leader is 570, single season is 57. More SBs, fewer strikeouts, more CG and SHO and pitcher endurance in general.
If anything, the problem I'm seeing is that pitchers aren't getting injured enough (on normal injury settings). Too many SPs go their entire career with only one or two DTD injuries, and that pushes their career stats a bit too high, leading to the plethora of 300-game-winners you can see here. But that isn't due to SkyDog's settings, and I can certainly live with it.