My league was hacked over night and a good majority of the files in my league domain's folder were deleted. I run a similar hosting setup as Zubes described and none of my other domains were touched.
This is the second hack job (the first being very minor - one page that had a malware ****** inserted), but given the constant attacks other folks are seeing, I'm not even sure it's worth doing a league any longer.
Prior to the FBL, I ran an OOTP league for 5 years (using versions 3 thru 6) and never got hacked. I started the FBL back up a few months ago and have been hacked twice that I know of... very frustrating.
NPBL Idaho Spuds GM
Former Federal Baseball League and JOBL Commish (2002 - 2011)