I have just ran single seasons. Playing out games, taking turns running each team.
Whats nice is you can change anything really and try out other stuff.
Default is no or low injuries, since you have a full 40 man roster, you can run normal injuries, I may try that out soon. I just have enjoyed playing with the all time greats, it would be rough to see Babe or The Kid go down with an injury, but you got plenty of people to pick you up.