| | | Sunday, October 8th, 1961 | | Activated LF Karl Fletcher from the disabled list. |
| Monday, October 2nd, 1961 | | Activated 3B Domingo Guerra from the disabled list. |
| Tuesday, September 19th, 1961 | | Placed 3B Domingo Guerra on the 13-day disabled list. |
| Monday, August 14th, 1961 | | Failed to sign 2nd round draft pick Dan Kramer. | | Failed to sign 6th round draft pick Elijah Jones. |
| Sunday, August 13th, 1961 | | Signed Brandon Young to a minor league contract with a signing bonus of $9,100. |
| Saturday, August 12th, 1961 | | Signed Sancho González to a minor league contract with a signing bonus of $24,100. |
| Thursday, August 10th, 1961 | | Signed 1st round draft pick Dan Sheffield for a signing bonus of $224,500 and a 3-year major league contract worth a total of $673,500. |
| Thursday, July 27th, 1961 | | Activated MR John Moser from the 60-day disabled list. | | MR Jessie Byer was designated for assignment and placed on irrevocable waivers. |
| Friday, June 23rd, 1961 | | Recalled SS José Mercado from Triple A Uxbridge. | | LF Nick Villa was designated for assignment and placed on irrevocable waivers. |
| Saturday, April 29th, 1961 | | Purchased the contract of SS José Mercado from Triple A Uxbridge. | | 2B David Carrillo was designated for assignment and placed on waivers (from active). |
| Wednesday, April 19th, 1961 | | Activated 2B Phil Fielding from the disabled list. | | SS José Mercado was designated for assignment and placed on irrevocable waivers. |
| Friday, April 14th, 1961 | | Placed MR John Moser on the 60-day disabled list. |
| Thursday, April 13th, 1961 | | Activated C Pedro Alfaro from the disabled list. | | C Trent Eaton was designated for assignment and placed on waivers (from active). |
| Monday, March 27th, 1961 | | Placed 2B Phil Fielding on the 13-day disabled list. |
| Thursday, December 22nd, 1960 | | SP Rob Flynn was designated for assignment and placed on irrevocable waivers. |
| Saturday, December 17th, 1960 | | Activated SP José Rodríguez from the 60-day disabled list. | | 2B David Carrillo was designated for assignment and placed on waivers (from active). |
| Thursday, December 1st, 1960 | | Optioned SP John Moser to Triple A Uxbridge. | | Drafted SP Brady Turner in the 1960 rule 5 draft (Pick 1, Round 1, 1st overall Pick), from the Los Angeles Quakes. | | SP Mitchell Gregg was designated for assignment and placed on irrevocable waivers. | | Drafted SP Don Hubbard in the 1960 rule 5 draft (Pick 1, Round 2, 17th overall Pick), from the San Francisco Golden Gators. | | MR Paul McCaslin was designated for assignment and placed on waivers (from active). | | Drafted SP Ernest Dunn in the 1960 rule 5 draft (Pick 1, Round 3, 33rd overall Pick), from the Boston Colonials. | | Optioned MR Orsino Gabbiadini to Triple A Uxbridge. | | Drafted SP Jessie Byer in the 1960 rule 5 draft (Pick 1, Round 4, 49th overall Pick), from the Baltimore Barons. |
| Wednesday, November 2nd, 1960 | | Activated CF Vincente Ibarra from the 60-day disabled list. | | RF César García was designated for assignment and placed on irrevocable waivers. |
| Thursday, October 27th, 1960 | | Signed team doctor Jim Donaldson to a 3-year, $19,400 per year contract. |
| Saturday, October 22nd, 1960 | | Signed general manager Roberto Estrada to a 4-year, $31,300 per year contract. |
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