| | | Friday, August 13th, 1965 | | Placed LF Wilson Colón on the 15-day disabled list. |
| Monday, July 12th, 1965 | | Activated 2B Earl Quick from the disabled list. |
| Monday, June 21st, 1965 | | Placed 2B Earl Quick on the 15-day disabled list. |
| Tuesday, June 15th, 1965 | | Promoted RF Brian Harris to Double A Corpus Christi. | | Received SP Martín García from Double A Corpus Christi. | | Received SS Giovani Pajetta from Double A Corpus Christi. | | Drafted 1B Ryan Sherman in the 1965 first-year player draft (Round 7, Pick 6, 127th overall pick). | | Drafted SP Joe Tracy in the 1965 first-year player draft (Round 8, Pick 6, 145th overall pick). | | Drafted C Marlon Hicks in the 1965 first-year player draft (Round 9, Pick 6, 163rd overall pick). | | Drafted MR Kyle Donnelly in the 1965 first-year player draft (Round 10, Pick 6, 181st overall pick). | | Placed SP Bill Davidson on the 15-day disabled list. |
| Tuesday, March 16th, 1965 | | Activated SP Ben Shaffer from the disabled list. |
| Wednesday, January 6th, 1965 | | Activated SP Adrian Keller from the disabled list. |
| Thursday, September 10th, 1964 | | Activated MR Martín García from the disabled list. |
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