| Friday, April 24th, 1981 | | St. Louis Dredgers: SS Raúl Saucedo was injured when he fell asleep at the wheel. The Diagnosis: shoulder soreness. This is a day-to-day injury expected to last one week. |
| Tuesday, April 21st, 1981 | | Washington Mutuals: LF Qing-nian Qin was injured while throwing the ball. The Diagnosis: forearm cramp. This is a day-to-day injury expected to last 4 days. | | New York Empires: SP Benjamin Britt was injured while pitching. The Diagnosis: strained oblique. He's expected to miss about 4 weeks. |
| Tuesday, April 14th, 1981 | | Atlanta Rebels: LF Chia-ch'ing Mo was injured on a defensive play. The Diagnosis: fractured fibula. He's expected to miss about 3 months. | | New York Empires: CF Tim Waller was injured in a collision at a base. The Diagnosis: shoulder tendinitis. He's expected to miss about 4 weeks. | | Chicago Clout: CF Manuel Acosta was injured while running the bases. The Diagnosis: back tightness. This is a day-to-day injury expected to last 3 days. | | Los Angeles Quakes: MR Pedro Osorio was injured while pitching. The Diagnosis: back stiffness. This is a day-to-day injury expected to last 6 days. | | Baltimore Barons: MR Aurelio Domínguez was injured while pitching. The Diagnosis: forearm stiffness. He's expected to miss about one week. | | Cleveland Eagles: CF Drew Key was injured on a defensive play. The Diagnosis: mild hamstring strain. This is a day-to-day injury expected to last 1-2 weeks. |
| Monday, April 13th, 1981 | | Chicago Clout: MR Earl Young was injured while pitching. The Diagnosis: radial nerve (elbow) decompression surgery. He's expected to miss about 5 months. | | San Antonio Revenge: CF Augusto Botequim was injured while running the bases. The Diagnosis: knee soreness. He's expected to miss about 4 days. |
| Saturday, April 11th, 1981 | | Cleveland Eagles: 2B José Gómez was injured while running the bases. The Diagnosis: hamstring spasms. This is a day-to-day injury expected to last 4 days. |
| Friday, April 10th, 1981 | | Boston Colonials: MR Hervé Leconte was injured while pitching. The Diagnosis: herniated disc (back). He's expected to miss about 4 weeks. | | Chicago Clout: 2B Armando Méndez was injured while running the bases. The Diagnosis: hamstring strain. He's expected to miss about 5 weeks. |
| Tuesday, April 7th, 1981 | | Atlanta Rebels: MR Richard Campbell was injured while pitching. The Diagnosis: biceps tendinitis. He's expected to miss about 3-4 weeks. | | San Antonio Revenge: MR Raúl Soto was injured while pitching. The Diagnosis: torn UCL (Tommy John surgery). He's expected to miss about 12-13 months. | | Chicago Clout: MR Curt Jones was injured while pitching. The Diagnosis: partially torn labrum. He's expected to miss about 3 months. |
| Monday, April 6th, 1981 | | Los Angeles Quakes: 1B Nathan Raymond was injured in a collision at a base. The Diagnosis: sprained ankle. He's expected to miss about 2 weeks. |
| Friday, April 3rd, 1981 | | Houston Bullfighters: 2B Ellis Caldicott was injured after getting in a fight during a poker game. The Diagnosis: bruised ankle. This is a day-to-day injury expected to last 4 days. |
| Wednesday, April 1st, 1981 | | Detroit Bears: LF Ramiro Gómez was injured while throwing the ball. The Diagnosis: mild hamstring strain. This is a day-to-day injury expected to last 3 days. | | Detroit Bears: MR Júlio Rodríguez was injured while pitching. The Diagnosis: rotator cuff inflammation. He's expected to miss about 3 months. | | New York Empires: MR Gabriel Balderas was injured while pitching. The Diagnosis: sore elbow. This is a day-to-day injury expected to last 3 days. | | Washington Mutuals: RF Kirk Moore was injured being hit by a pitch. The Diagnosis: bruised knee. This is a day-to-day injury expected to last one week. |
| Tuesday, March 31st, 1981 | | Manhattan Peril: SP Ed Larsen was injured while pitching. The Diagnosis: back tightness. This is a day-to-day injury expected to last 3 days. | | Phoenix Aces: 3B Eric Savage was injured while running the bases. The Diagnosis: sore hamstring. This is a day-to-day injury expected to last 2 days. | | Phoenix Aces: SS Enrique Contreras was injured while running the bases. The Diagnosis: calf soreness. This is a day-to-day injury expected to last 4 days. | | Cincinnati Rivermen: C Rodney White was injured on a defensive play. The Diagnosis: sprained finger. He's expected to miss about 2 weeks. |
| Monday, March 30th, 1981 | | The Bronx Ironmen: LF Norman Nichols was injured on a defensive play. The Diagnosis: strained back. He's expected to miss about 2 weeks. | | Atlanta Rebels: 3B Bernard Jones was injured while running the bases. The Diagnosis: bruised knee. This is a day-to-day injury expected to last 2 days. |
| Friday, March 27th, 1981 | | New York Empires: 2B Iván Pacheco was injured in a collision at a base. The Diagnosis: fractured finger. He's expected to miss about 8 weeks. | | Boston Morrills: RF Manny Adkins was injured while running the bases. The Diagnosis: hamstring tightness. This is a day-to-day injury expected to last 5 days. | | Washington Mutuals: RF Kirk Moore was injured being hit by a pitch. The Diagnosis: bruised knee. This is a day-to-day injury expected to last 5 days. |
| Thursday, March 26th, 1981 | | Phoenix Aces: LF Manny Olivarez was injured while running the bases. The Diagnosis: knee inflammation. He's expected to miss about 2 weeks. |
| Wednesday, March 25th, 1981 | | Atlanta Rebels: LF Chia-ch'ing Mo was injured while running the bases. The Diagnosis: strained hamstring. He's expected to miss about 2 weeks. | | Boston Colonials: SP Manuel Méndez was injured while pitching. The Diagnosis: sore shoulder. He's expected to miss about 4 days. | | Cincinnati Rivermen: MR Leonard Erickson was injured while pitching. The Diagnosis: strained back. This is a day-to-day injury expected to last one week. | | San Antonio Revenge: 1B Dave Schermerhorn was injured while throwing the ball. The Diagnosis: mild hamstring strain. This is a day-to-day injury expected to last 3 days. | | New York Empires: SS Tom Thomas was injured while running the bases. The Diagnosis: sore hamstring. This is a day-to-day injury expected to last 2 days. |
| Tuesday, March 24th, 1981 | | Phoenix Aces: 2B Paul Thames was injured while running the bases. The Diagnosis: bruised thumb. This is a day-to-day injury expected to last 3 days. | | Manhattan Peril: RF Mike Knight was injured on a defensive play. The Diagnosis: oblique strain. He's expected to miss about 2-3 weeks. | | New York Empires: SP Christian Adams was injured while pitching. The Diagnosis: sore shoulder. He's expected to miss about 5 days. | | Boston Morrills: MR Felipe Luna was injured while pitching. The Diagnosis: mild shoulder inflammation. He's expected to miss about 2 weeks. |
| Monday, March 23rd, 1981 | | Boston Colonials: SS Jason Thomas was injured while throwing the ball. The Diagnosis: strained bicep tendon. He's expected to miss about 4 weeks. | | The Bronx Ironmen: 3B Cipriano Bonilla was injured while throwing the ball. The Diagnosis: strained shoulder. He's expected to miss about 5 weeks. | | Houston Bullfighters: LF Tony Ortíz was injured while throwing the ball. The Diagnosis: finger blister. This is a day-to-day injury expected to last 5 days. |
| Sunday, March 22nd, 1981 | | Atlanta Rebels: SS Franklin Pelley was injured while running the bases. The Diagnosis: knee inflammation. He's expected to miss about 4 days. |
| Saturday, March 21st, 1981 | | St. Louis Dredgers: LF David Hernández was injured on a defensive play. The Diagnosis: sprained ankle. He's expected to miss about one week. | | Detroit Bears: 2B Dave Day was injured while running the bases. The Diagnosis: knee inflammation. He's expected to miss about 2-3 weeks. | | Boston Morrills: MR Manuel Pérez was injured while pitching. The Diagnosis: torn biceps. He's expected to miss about 3 months. | | Baltimore Barons: 3B David Bell was injured on a defensive play. The Diagnosis: intercostal strain. He's expected to miss about 4 weeks. |
| Saturday, March 7th, 1981 | | Boston Morrills: José Zapata has suffered a setback in his recovery. He is not expected to recover for another 2-3 months. |
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