| Thursday, April 9th, 1981 |
| Received SP Pedro Hernández from Major League Level Cleveland. |
| Received MR Orestes Enes from Major League Level Cleveland. |
| Received C Siméon Martin from Major League Level Cleveland. |
| Received SS Roberto Uribes from Major League Level Cleveland. |
| Received 2B Manny Herrera from Major League Level Cleveland. |
| Received SS Gerardo Amaya from Major League Level Cleveland. |
| Received 3B Terrence Sinclair from Major League Level Cleveland. |
| Received RF Ju-ao Loong from Major League Level Cleveland. |
| Received RF John Adams from Major League Level Cleveland. |
| Received 1B Rob Eckersley from Major League Level Cleveland. |
| Received 2B José Ortíz from Major League Level Cleveland. |
| Received RF Alfonso Márquez from Major League Level Cleveland. |
| Demoted SP Solano Rondo to Double A Port Lavaca. |
| Demoted SP John Williams to Double A Port Lavaca. |
| Demoted SP Lee Waters to Double A Port Lavaca. |
| Demoted MR Dominic Byrd to Double A Port Lavaca. |
| Demoted 1B Dave Reed to Double A Port Lavaca. |
| Demoted 2B Jorge García to Double A Port Lavaca. |
| Demoted 1B Ricardo Ortíz to Double A Port Lavaca. |
| Demoted SS Fernando Parra to Double A Port Lavaca. |
| Demoted CF Lawrence Williams to Double A Port Lavaca. |
| Demoted RF Tony Fernández to Double A Port Lavaca. |
| Demoted 1B Matt Ramage to Double A Port Lavaca. |
| Demoted SS Wilson Rodríguez to Double A Port Lavaca. |
| Demoted LF Orlando Pérez to Double A Port Lavaca. |
