| Monday, September 22nd, 1980 |
| Promoted MR Ippei Gato to Triple A Oshawa. |
| Promoted CL Júlio Longoria to Triple A Oshawa. |
| Promoted MR Anthony Simms to Triple A Oshawa. |
| Promoted 2B Tony Gamboa to Triple A Oshawa. |
| Promoted LF R.J. Stewart to Triple A Oshawa. |
| Promoted 1B Luke Weston to Triple A Oshawa. |
| Promoted CF Joe Rodgers to Triple A Oshawa. |
| Promoted 3B Dave Sexton to Triple A Oshawa. |
| Received SP Chris Miller from Single A Whittier. |
| Received MR Jesús Nieves from Single A Whittier. |
| Received MR Miguel Ramos from Single A Whittier. |
| Received SP Walt Boucher from Single A Whittier. |
| Received LF Juan Luna from Single A Whittier. |
| Received 3B Mark Kelly from Single A Whittier. |
| Received RF Mike Clark from Triple A Oshawa. |
| Received RF Scott Parker from Single A Whittier. |
| Received RF Allen Brock from Single A Whittier. |
| Received RF Pancho Vega from Single A Whittier. |
| Received RF Christian Bean from Single A Whittier. |
| Received 1B Oscar Norman from Single A Whittier. |
| Received 1B Rob Moon from Single A Whittier. |
| Received SS Elwood Allen from Single A Whittier. |
| Received SP Dani Muñóz from Triple A Oshawa. |
| Received MR Anthony Simms from Triple A Oshawa. |
| Received C Ron Alston from Triple A Oshawa. |
| Received C Carl Dempsey from Triple A Oshawa. |
| Received 2B Miguel López from Major League Level Boston. |
| Received SS Gustavo Villegas from Major League Level Boston. |
| Received SS William Fisher from Triple A Oshawa. |
| Received 2B Jorge Salas from Triple A Oshawa. |
| Received LF Joe Rodgers from Triple A Oshawa. |
| Received 1B Luke Weston from Triple A Oshawa. |
| Received 3B Andrés Estrada from Triple A Oshawa. |
| Received 1B Hal Kirby from Triple A Oshawa. |
| Received 2B Tony Gamboa from Triple A Oshawa. |
| Received LF R.J. Stewart from Triple A Oshawa. |
| Demoted SP Nelson Martínez to Single A Whittier. |
| Demoted MR Walt Boucher to Single A Whittier. |
| Demoted C José Tirado to Single A Whittier. |
| Demoted C Ricardo Mojica to Single A Whittier. |
| Demoted LF Juan Luna to Single A Whittier. |
| Demoted 3B Rafael Sierra to Single A Whittier. |
| Demoted 2B Mark Kelly to Single A Whittier. |
| Demoted CF Mike Clark to Single A Whittier. |
| Demoted RF Scott Parker to Single A Whittier. |
| Demoted RF Pancho Vega to Single A Whittier. |
| Demoted RF Christian Bean to Single A Whittier. |
| Demoted 1B Oscar Norman to Single A Whittier. |
| Demoted 1B Rob Moon to Single A Whittier. |
| Demoted SS Elwood Allen to Single A Whittier. |
| Activated 2B Bob Conner from the disabled list. |
