| | | Friday, August 15th, 1980 | | Activated 3B Edward Barnes from the disabled list. |
| Saturday, July 26th, 1980 | | Placed 3B Edward Barnes on the 15-day disabled list. |
| Sunday, July 13th, 1980 | | Activated CF Will Bass from the disabled list. |
| Saturday, June 28th, 1980 | | Placed CF Will Bass on the 15-day disabled list. |
| Sunday, June 15th, 1980 | | Drafted SP Andrew Hill in the 1980 first-year player draft (Round 6, Pick 2, 106th overall pick). | | Drafted SS Iván Rocha in the 1980 first-year player draft (Round 7, Pick 2, 127th overall pick). | | Drafted MR Moustafa Fumu in the 1980 first-year player draft (Round 8, Pick 2, 147th overall pick). | | Drafted 3B Raúl Blanco in the 1980 first-year player draft (Round 9, Pick 2, 167th overall pick). | | Drafted MR Travis Brown in the 1980 first-year player draft (Round 10, Pick 2, 187th overall pick). | | Promoted 2B Robbie Scott to Double A Greensboro. | | Promoted 3B Ted Newell to Double A Greensboro. |
| Monday, May 26th, 1980 | | Activated LF Felipe Delgado from the disabled list. |
| Saturday, May 17th, 1980 | | Placed SS Anastasio Pérez on the 15-day disabled list. |
| Sunday, May 11th, 1980 | | Placed LF Felipe Delgado on the 15-day disabled list. |
| Thursday, May 8th, 1980 | | Activated SP Morgan Cole from the disabled list. |
| Wednesday, February 27th, 1980 | | Activated C Leon Campbell from the disabled list. |
| Tuesday, February 12th, 1980 | | Placed C Leon Campbell on the 15-day disabled list. |
| Thursday, August 23rd, 1979 | | Signed Manager Bob Rowe to a 3-year contract extension. | | Released 2B Vincent Curtis. |
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